New, Aggressive Strain of HIV Identified in Cuba

A paper (1) in the journal EBioMed has discussed the discovery of a new strain of HIV which seems to be especially aggressive and progresses to AIDS from HIV infection within a very short time. This strain, found in Cuba, raises new questions about the chemotherapy for HIV Infection.

HIV is an immunologically complex virus having a number of strains, basics of which include:

Certain types of Circulating Recombinant Types or Forms (CRF) have been noted to be of an aggressive nature, with the time lag between occurrence of HIV infection and onset of full blown AIDS being very short in the absence of antiretroviral therapy. Usually, in these patients, by the time ART is started it is too late and they suffer through all the complications of AIDS.

The next phase that is of interest is to see if this Cuban strain goes global and if it does whether it keeps replicating the same virulence across geographical areas. The concern is that with the emergence of such virulent strains, the fight against HIV/AIDS is unlikely end any time soon and will rage on for the years to come.

Kouri V, Khouri R, Aleman Y, et al. CRF19_cpx is an Evolutionary fitHIV-1 Variant Strongly Associated With Rapid Progression to AIDS in Cuba. EBioMedicine; doi: 10.1016/j.ebiom.2015.01.015. In press. Available online at Accessed on May 30, 2015.

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