Cholera Case in Syrian Refugee Camp: Ominous Signals

According to a report disseminated by the ProMED mail service, a case of cholera has been detected in a refugee camp housing displaced people from Homs. The translated report reads as below: The 1st case of cholera has been recorded in Zogra camp near Jarabulus city (125 km or 78 mi north of Aleppo) at the Syrian-Turkish border, which accommodates people displaced from Homs. A … Continue reading Cholera Case in Syrian Refugee Camp: Ominous Signals

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Clinical Research in Times of Ebola… and other Epidemics

As the news trickles in about the raging cholera outbreak in Yemen, and an emerging outbreak is being dealt with urgently in North-Eastern Nigeria, we are more frequently being confronted with the uncomfortable question of leveraging these situations to conduct clinical research activities. The National Academies of Science, Engineering and Medicine (NASEM) have come out with a report dealing with exactly this quandary. This report, … Continue reading Clinical Research in Times of Ebola… and other Epidemics

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The Manhattan Principles

From the CDC Webpage on the twelve Manhattan Principles: These “Manhattan Principles” urge world leaders, civil society, the global health community, and institutions of science to holistically approach the prevention of epidemic/epizootic disease and the maintenance of ecosystem integrity by: Recognizing the link between human, domestic animal, and wildlife health, and the threat disease poses to people, their food supplies and economies, and the biodiversity … Continue reading The Manhattan Principles

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Comparing the Rotavirus Vaccines in India

Comparisons of different rotavirus vaccines are difficult to make with a lot of precision because of the differing populations, protocols, attack rates, and study procedures which have been employed to assess the efficacy of the vaccines. Given the rather recent deployment of the vaccines, there are very limited evidence on their effectiveness in the population/community-setting. Features Rotavac Rotasiil Type Live attenuated vaccine Live attenuated vaccine … Continue reading Comparing the Rotavirus Vaccines in India

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BGR-34 for Diabetes: Where is the evidence?

An herbal drug, developed jointly by the National Botanical Research Institute (NBRI) and the Central Institute of Medicinal and Aromatic Plants (CIMAP), branded as BGR-34, has been commercialized by Delhi-based Aimil Pharmaceuticals and marketed as a potentially side-effect free treatment for diabetes. However, a search for publications outlining trials conducted to support the claimed “67% success rate”, came up empty for me. And I am … Continue reading BGR-34 for Diabetes: Where is the evidence?

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Turning to the “Infected Jelly” to Treat Ebola

The NEJM has come out with a very interesting paper: Evaluation of Convalescent Plasma for Ebola Virus Disease in Guinea. The explosive outbreak of Ebola Virus Disease in West Africa last year had hijacked the headlines and media space in a big way. Multiple solutions were touted, including the vaccine trial STRIVE. Few articles, however, looked at the systems response to the crisis. Although the current … Continue reading Turning to the “Infected Jelly” to Treat Ebola

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