Comic Book Meets Medicine: Little Orphan Annie

One of the classic histopathological signs that we read of in Pathology quite often is the Orphan Annie Eye nucleus seen in Papillary carcinoma of the thyroid. This odd name has an interesting history behind it. One that dates back to two popcult references – one at the fag end of the 1800s and one that started slightly later, in 1924. The Bethesda guidelines for … Continue reading Comic Book Meets Medicine: Little Orphan Annie

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